EXACT SCIENCES EXPLOITS ADVANCES IN COLON CANCER DETECTION $EXAS $HOLX

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EXACT SCIENCES EXPLOITS ADVANCES IN COLON CANCER DETECTION $EXAS $HOLX

In the United States, 50,000 people die from colon cancer each year and 140,000 new cases are reported every year.  As cancer goes, colon cancer is second only to lung cancer as the biggest killer in the United States. Fortunately, for the most part, colon cancer is easily preventable because it typically starts as non-cancerous polyps that sometimes develop into cancer over a prior of five to 15 years.

The gold standard for early polyp detection is colonoscopy.  A colonoscopy requires preparation to clean the colon for one to two days.  A thin flexible tube with a video camera at the end is inserted into the colon through the rectum.  At present guidelines call for regular screening for colon cancer starting at age 50 using both invasive and non-invasive methods. Colonoscopy is an invasive method; non-invasive methods include immunochemical-based fecal occult blood testing (FIT) and guaiac-based fecal occult blood testing (gFOBT). Unfortunately compliance with the guidelines is poor, only about 33% of people over the age of 50 undertake screening. The main reasons are that people simply do not like prepping for colonoscopy and undergoing this invasive procedure, the FIT test is non-invasive but only 74% accurate.

The Food and Drug Administration (FDA) advisory panel has unanimously recommended approval of a new home test Cologuard developed by Exact Sciences Corporation (EXAS).  FDA typically follows the recommendation of the panel.

By using DNA markers in a lab on stool samples that may be collected at home, Exact Sciences showed in a large study detection of 92% of cancers compared to 74% from the FIT test…Read more at Forbes

 

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